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UniQuell is made with a unique mix of ingredients shown in studies to act on numerous pathways to reduce negativity and worry and replace it with positivity and optimism. Below is an overview of the science behind UniQuell's approach and ingredients.

Amino Acid Neurotransmitters

Glutamate:
The most abundant excitatory neurotransmitter in the body, glutamate is responsible for learning, memory and many other functions in the brain. Recently glutamate, and more specifically NMDA receptors that it acts on, have been implicated in controlling mood. [1] Substances that reduce interaction between glutamate and NMDA receptors have been shown to cause an immediate boost in mood. [2]

GABA (gamma-aminobutyric acid):
The most abundant inhibitory neurotransmitter in the body, GABA and glutamate are part of a never ending balancing act, with GABA calming the mind, and glutamate stimulating it. Increasing GABA levels has been shown to promote feelings of calmness and reductions in anxiety. [3] Activation of GABAB receptors has been shown to improve mood and influence the serotonin system. [4]

Endorphins

Primarily responsible for feelings of happiness and wellbeing. Endorphins reduce pain and increase enjoyment of activities.[8]

Inflammation

Brain inflammation has been shown in studies to increase glutamate levels in the brain, which activate the NMDA receptor. [12][13]

Monoamine Neurotransmitters

Serotonin:
Serotonin is involved the in regulation of emotion and plays a key role in emotional processing, a sort of emotional lens that you view the world through. [5]

Dopamine:
Primarily responsible for motivation, focus and drive. Dopamine is considered the reward system within the brain. There is a direct link between dopamine levels and mood. Low levels cause a worsening of mood and extremely high levels cause mania, or abnormally elevated mood. [6]

Norepinephrine:
Primarily responsible for feelings of alertness, energy and focus and control, low norepinephrine levels can have a negative impact on mood. [7]

Nitric Oxide

Nitric oxide is a highly versatile molecule in the human body, responsible for a wide variety of activities. Levels of nitric oxide in the brain have been shown to have a strong correlation with mood. [9] Nitric Oxide has been shown to convert serotonin to an inactive form[10], prevent the release of dopamine and norepinephrine[11] and increase glutamate release. [12]

The Ingredients

Agmatine
In studies Agmatine Sulfate has been shown to reduce NMDA receptor activity [14], enhance the bodies endorphin effectiveness and production [15] [16][17] and reduce nitric oxide production [18]. Reducing nitric oxide synthesis in the brain has been shown to relieve anxiety in mice [19]

Rhodiola Rosea
Standardized Rhodiola Rosea, such as that found in UniQuell has been shown to reduce anxiety and improve mood and stress resistance. [20] [21] [22]

In studies Rhodiola Rosea has been shown to achieve these effects by inhibiting the Catechol-O-methyltransferase enzyme (COMT), which is responsible for the breakdown of dopamine and norepinephrine. Genetic research has shown that a common mutation in the COMT enzyme has been linked to dramatically decreased enjoyment in various activities. [23] COMT is a major mode of dopamine and norepinephrine breakdown and the primary mode in the prefrontal cortex, a region of the brain associated with planning, decision making and emotional regulation. [24]

BCM-95 Curcumin Extract:
Curcumin has been shown to have potent anti-inflammatory and mood boosting effects by acting on more pathways than any other herb we know of. Curcumin has an impact on glutamate, serotonin, dopamine, norepinephrine, and nitric oxide, as well as having powerful antioxidant and antiinflammatory effects. [25]

Unfortunately curcumin's bioavailability (the amount absorbed and utilized by the body) is rather low. Fortunately triple patented BCM-95, Curcumin Extract, has been shown to have 693% greater bioavailability than pure curcumin resulting in therapeutic levels of curcumin reaching the blood faster, at higher levels and for a longer time. [26]

Lemon Balm
Low dose Lemon Balm like that found in UniQuell has been shown to be calming and to have mood elevating properties. [27]

Lemon Balm, also known as Melissa Officinalis, has been shown to be a potent inhibitor of GABA transaminase, the enzyme that breaks down GABA, greatly increasing GABA levels.[28]

Magnesium Glycinate
Magnesium is a vital nutrient that most people don't get enough of. 57.0% of Americans are considered to be magnesium deficient. [29] Magnesium is involved in regulation of nitric oxide production [30] and reduces the effects of glutamate on the NMDA receptor. [31] Low magnesium levels have been associated with a worsening of mood. Restoration of proper magnesium levels has been shown to rapidly improve mood. [29].